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Digestion is the first step to lipid metabolism, and it is the process of breaking the triglycerides down into smaller monoglyceride units with the help of lipase enzymes. Digestion of fats begin in the mouth through chemical digestion by lingual lipase.
Lipid metabolism is a complex process that involves multiple steps involving the dietary intake of lipids (exogenous) or the production of lipids within the body (endogenous) to degradation or transformation (catabolism) into several lipid-containing structures in the body.
Key enzymes that are involved in regulation of lipid metabolism are carnitine palmitoyltransferase 1, acetyl-coA carboxylase, fatty acid synthase, and 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Carnitine palmitoyltransferase 1 transfers fatty acid into the mitochondria for oxidation.
Vitamins play an essential role in lipid metabolism reactions and their presence is therefore absolutely necessary for these reaction to occur. … Other vitamins, like vitamin B12, folic acid, vitamin C, and essential fatty acids influence lipid metabolism by different mechanisms.
In skeletal and cardiac muscle, mitochondrial fatty acid oxidation leads to substrate production for the tricarboxylic acid (TCA) cycle, in the form of acetyl CoA, and provides ATP for the myocytes.
The liver plays a central role in all metabolic processes in the body. In fat metabolism the liver cells break down fats and produce energy. They also produce about 800 to 1,000 ml of bile per day. … Bile is important for the breakdown and absorption of fats.
Regulation of lipid metabolism by leptin, insulin and adiponectin. Insulin and leptin are secreted in direct proportion, and adiponectin in negative proportion, to the size of the adipose mass. These three hormones are key molecules in the regulation of lipid metabolism.
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People often experience an increase in body fat during menopause. This is linked with reduced estrogen levels, lower-quality sleep, and reductions in metabolism and muscle mass. Researchers have linked low estrogen levels with an increase in body fat, particularly abdominal fat.
Excess belly fat is extremely unhealthy. It’s a risk factor for diseases like metabolic syndrome, type 2 diabetes, heart disease and cancer (1). The medical term for unhealthy fat in the belly is “visceral fat,” which refers to fat surrounding the liver and other organs in your abdomen.